Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC 50 = 10-50 nM), both isoforms of PP2A (IC 50 = 0.5 nM) and PP3 (IC 50 = 4 nM). 1,2,3 It is a very weak inhibitor of PP2B (IC 50 > 2 μM) and does not inhibit PP2C or other phosphatases. 1,3 Presumably through these

This study concerns the distribution of 3H-okadaic acid (OA) in organs and biological fluids of Swiss mice having received a single dose per os of OA (50 ug/kg).The determination of the intestinal tissues and contents 24 hr after administration demonstrates a slow elimination of OA.

Add to favourites. 产品使用信息. 冈田酸以冻干粉形式保存。如需 1 mM 原液，则在 31.1 μl DMSO 中放入 25 μg 重新配制。使用浓度和处理时长根据所需效果进行调整，但通常的使用浓度为 10-1000 nM，时长 15-60 分钟。 Okadaic acid is a polyether fatty acid. It is a marine toxin produced by the genera of Prorocentrum and Dinophysis. Application Okadaic acid from Prorocentrum concavum has been used as a phosphatase inhibitor: • to inhibit protein phosphatase 2 in spermatocytes culture • to treat SH-SY5Y cells to prevent dephosphorylation to maintain tau Okadaic acid (OKA) is one of the main polyether toxins produced by marine microalgae which causes diarrhetic shellfish poisoning.

Lipid metabolism in visceral fat cells is correlated with metabolic syndrome and cardiovascular diseases. Okadaic-acid, a 38-carbon fatty acid isolated from the black sponge Halichondria okadai, can stimulate lipolysis by promoting the phosphorylation of several proteins in adipocytes. Okadaic Acid: Equivalent Term Ocadaic Acid: CAS Registry Number 78111-17-8 Definition : A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter.

Structure : Top Interacting Genes Okadaic Acid, Free Acid, >98%, CAS#78111-17-8, More than 1,000 labs worldwide have purchased Okadaic Acid or its salts from LC Labs, either directly from us or from our distributors and resellers (the latter resell under their own labels). This work describes the selection and identification of DNA aptamers that bind with high affinity and specificity to okadaic acid (OA), a lipophilic marine biotoxin that accumulates in shellfish. The aptamers selected using systematic evolution of ligands by exponential enrichment (SELEX) exhibited dissociation constants in the nanomolar range.

Keywords: Okadaic Acid, Diarrhetic Shellfish, protein kinases (PKs), threonine-specific (PSPs), tyrosine-specific (PTPs) enzymes, OKADAIC ACID CLASS INHIBITORS, Halichondria okadai, Pandoras acanthifolium, Dinophysis, Prorocentrum

3, s. 1000-1007. Okadaic acid blocks LLC-PK cells in mitosis LLC-PK cells were treated with various concentrations of okadaic acid (OA) to determine its effect on cell growth.

Okadaic acid is an inhibitor of the serine/theorine protein phosphatases PP1 (IC 50 = 15-20 nM) and PP2A (IC 50 = 0.1 nM), exhibiting much greater activity towards the latter. PP2A is completely inhibited at 1-2 nM, compared to greater than 1 µM for PP1 (1).

in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Buy Okadaic Acid Sodium Salt - an affordable, high quality PP1 Inhibitor from Hello Bio, a trusted supplier for life science researchers worldwide. Okadaic Acid is one of the toxins associated with diarrheic shellfish poisoning ( DSP).

”The first observation of okadaic acid in. Mytilus edulis from the Gulf of Finland”.
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This toxin potently and specifically inhibits PP-1 and PP-2A, although with different IC 50 concentrations.

Okadaic Acid exhibits various activities as follows: Contractile effect on smooth muscles in Ca 2+ free solution.
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Okadaic acid (OA) and other toxins of the diarrheic shellfish poisoning (DSP) group are accumulated and transformed mainly in many bivalves, inside the digestive gland cells. In this work the absorption of okadaic acid by those cells has been studied by supplying the toxin dissolved in water and including it in oil droplets given to primary cell cultures, and by checking if the uptake is

cenário. Dinoflagellates are unicellular protozoans and this specific one produces okadaic acid, associated with diarrhoeic shellfish poisoning. Charl MalanEvolution. av CG Gahmberg — Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of. CD11/CD18 leukocyte integrin with phorbol esters or CD3. OA från svenska till engelska.